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Expression heatmaps of differentially expressed genes between samples were obtained based on a log2 fold change using the ComplexHeatmap 2.0.0 (Gu, Eils, et Schlesner 2016, RRID:SCR_017270) package in R/Bioconductor

Short-Term Storage (up to two weeks): Store at 4C

So, it could be concluded that upon conjugation with glutathione, the selectivity of epothilone towards the tumor cell lines was strongly increased by two folds, ensuring the higher solubility of the conjugate that facilitates the penetration of the drugs across the plasma membrane via the ATP-Binding Cassette (ABC) proteins ABCC1 that called GSH-S-conjugate pump [6]

Glutathione is a naturally occurring antioxidant that is produced by the liver

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However, further studies are needed